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The scientific rationale utilizing the ideas of risk management for the choice of the manufacturing, filling, packaging processes, and storage circumstances that can affect drug product quality and efficiency should be defined and linked to the QTPP.
If important information of the drug substance or drug product is not available on the time that a S(A)NDS for a post-NOC change is submitted, the application should mirror the requirements listed in this High quality (C&M) Steering: NDSs and ANDSs guidance document.
For drug products requesting a waiver of the necessities to exhibit in vivo comparative studies for an aqueous solution, a comparison of the related pharmaceutical traits of the take a look at product and the Canadian Reference Product ought to be offered.…
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